CD73-IN-19
CD73-IN-19 (Compound 4ab) is a CD73 inhibitor (with a 44% inhibition rate of CD73 enzymatic activity at 100 μM) . CD73-IN-19 (at 10 μM and 100 μM) can completely antagonize the blockade of T cell proliferation induced by TCR (T cell receptor) triggering (which is induced by CD73 activity), and it can also inhibit the hA2A receptor activity in HEK-293 cells (Ki is 3.31 μM) . CD73-IN-19 holds promise for research in the field of immune diseases[1].
Product Specifications
CAS Number
[333329-22-9]
UNSPSC
12352005
Target
CD73
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=C(NC(C2=C(N)C3=C(C)C=C(C)N=C3S2)=O)C=C1)OC
Molecular Formula
C18H17N3O3S
Molecular Weight
355.41
References & Citations
[1]Grosjean F, et al. Third-Generation CD73 Inhibitors Based on a 4,6-Disubstituted-2-Thiopyridine Scaffold. ChemMedChem. 2024 Dec 13:e202400662.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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