RU-0415529
RU-0415529 is an orally active inhibitor for SARS-CoV-2 nonstructural protein 14 (NSP14) with an IC50 of 356 nM. RU-0415529 binds to the SAH-stabilized cap binding pocket, inhibits viral RNA methylation and the viral replication. RU-0415529 exhibits anti-infectious activity in mouse models[1].
Product Specifications
CAS Number
1358734-35-6
UNSPSC
12352005
Target
DNA Methyltransferase; SARS-CoV
Related Pathways
Anti-infection; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
CC1CCN(S(=O)(C2=C(C)N(C)C(C(NCC3=CC=CC=C3OC)=O)=C2)=O)CC1
Molecular Formula
C21H29N3O4S
Molecular Weight
419.54
References & Citations
[1]Meyer C, et al., Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase. Nature. 2024 Dec 11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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