PKMYT1-IN-8
PKMYT1-IN-8 (Compound 137) is the inhibitor for PKMYT1 with an IC50 of 9 nM. PKMYT1-IN-8 inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2with IC50s of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. PKMYT1-IN-8 inhibits the proliferation of cancer cell OVCAR3 with GI50 of 2.02 μM[1].
Product Specifications
UNSPSC
12352005
Target
Ephrin Receptor; Wee1
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.31
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=NC(C(F)(F)F)=C2C(N(C3=C(C)C=CC(O)=C3C)C(N)=C2C(N)=O)=N1
Molecular Formula
C17H16F3N5O2
Molecular Weight
379.34
References & Citations
[1]Avipsa Ghosh, et al., Pyrrolopyrimidinecarboxamides as PKMYT1 inhibitors and their preparation. WO2024252276.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKMYT1
Available Sizes
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