Ferroptosis-IN-17
Ferroptosis-IN-17 (Compound 18) is a ferroptosis (Ferroptosis) inhibitor with an EC50 value of 0.57 μM. Ferroptosis-IN-17 reduces intracellular ferrous ion accumulation, lipid peroxidation, and effectively restores the levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4) . Ferroptosis-IN-17 shows good solubility and significant metabolic stability in rat plasma. Ferroptosis-IN-17 is promising for research in tumor suppression, neurodegenerative diseases, and cardiovascular diseases[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Smiles
O=C(NCC)C1=CC=C(NC2CCCCC2)C(NS(=O)(C3=CC=C([N+]([O-])=O)C=C3)=O)=C1
Molecular Formula
C21H26N4O5S
Molecular Weight
446.52
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
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