KB-208

KB-208 is a phagocytosis inhibitor that acts similarly to intravenous immunoglobulin (IVIG) . KB-208 improves immune thrombocytopenia (ITP) in a mouse model at a dose of 1 mg/kg. KB-208 does not affect other blood parameters and does not elevate serum biochemical markers of toxicity, and can be used in research in the field of immunity[1][2].

Product Specifications

CAS Number

[1282128-68-0]

UNSPSC

12352005

Target

Others

Related Pathways

Others

Field of Research

Inflammation/Immunology

Concentration

10mM

Purity

98.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CC1CCN(CC1)C(C2=CC(C3=CC=CS3)=NN2C4=CC=CC=C4)=O)OC

Molecular Formula

C22H23N3O3S

Molecular Weight

409.50

References & Citations

[1]Loriamini M, et al. A novel small molecule phagocytosis inhibitor, KB-208, ameliorates ITP in mouse models with similar efficacy as IVIG. Transfusion. 2024 Dec;64 (12) :2233-2240.|[2]Aşık A, et al. Amcasertib Increases Apoptosis While Decreasing Invasive and Migrating Abilities in Breast Cancer Stem Cells[J]. Clinical and Experimental Health Sciences, 2024, 14 (3) : 800-806.