MAT2A-IN-20
MAT2A-IN-20 (Compound A49) is an inhibitor for methionine adenosyltransferase 2A (MAT2A) with an IC50 ≤50 nM. MAT2A-IN-20 inhibits human UGT1A1 with an IC50 of 28.45 μM. MAT2A-IN-20 exhibits antitumor in mouse models[1].
Product Specifications
CAS Number
[3018834-98-2]
UNSPSC
12352005
Target
Methionine Adenosyltransferase (MAT)
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C1C(C2=CC3=C(N=C(C(C)(C)O)N3C)C=C2)=NC4=C(N1C5=CC=C(C=C5)OC(F)F)N=C(OCC)N=C4
Molecular Formula
C26H24F2N6O4
Molecular Weight
522.50
References & Citations
[1]Wang K, et al., Pyrimido nitrogen-containing six-membered aromatic heterocyclic compound and application thereof. CN115504980A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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