GABA-A Receptor Ligand-1
GABA-A Receptor Ligand-1 (Compound 4) is a ligand for GABA-A receptor with a pKi of 7.27. GABA-A Receptor Ligand-1 reduces mitochondrial dysfunction, promotes neurite outgrowth and neuronal regeneration. GABA-A Receptor Ligand-1 exhibits neuroprotective efficacy in rats ischemic stroke models[1].
Product Specifications
CAS Number
[3076335-23-1]
UNSPSC
12352005
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC(C=C1)=CN2C1=NC(C3=CC=C(C=C3)F)=C2CC(N4CCCC4)=O
Molecular Formula
C20H20FN3O
Molecular Weight
337.39
References & Citations
[1]Mordyl B, et al., Preferential Synaptic Type of GABA-A Receptor Ligands Enhancing Neuronal Survival and Facilitating Functional Recovery After Ischemic Stroke. J Med Chem. 2024 Dec 26;67 (24) :21859-21889.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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