EGFR-IN-140

EGFR-IN-140 (Compound 31) is the inhibitor for EGFR, that inhibits EGFR wildtype and EGFR L858R/T790M/C797S mutant with Ki of 0.95 nM and 2.1 nM, and inhibits EGFR del19/T790M/C797S in Ba/F3 with an IC50 of 56.9 nM. EGFR-IN-140 exhibits antitumor efficacy in mouse model[1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CN(CC[C@@]12CC[C@H](N3C4=CC(NC5=NC(N6CC[C@@H](OC)[C@@H](F)C6)=NC=C5)=NN4C=C3CC)CC2)C1=O

Molecular Formula

C27H37FN8O2

Molecular Weight

524.63

References & Citations

[1]Igawa H, et al., Discovery of a Novel Mutant-Selective Epidermal Growth Factor Receptor Inhibitor Using an In Silico Enabled Drug Discovery Platform. J Med Chem. 2024 Dec 26;67 (24) :21811-21840.