EGFR-IN-140
EGFR-IN-140 (Compound 31) is the inhibitor for EGFR, that inhibits EGFR wildtype and EGFR L858R/T790M/C797S mutant with Ki of 0.95 nM and 2.1 nM, and inhibits EGFR del19/T790M/C797S in Ba/F3 with an IC50 of 56.9 nM. EGFR-IN-140 exhibits antitumor efficacy in mouse model[1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CN(CC[C@@]12CC[C@H](N3C4=CC(NC5=NC(N6CC[C@@H](OC)[C@@H](F)C6)=NC=C5)=NN4C=C3CC)CC2)C1=O
Molecular Formula
C27H37FN8O2
Molecular Weight
524.63
References & Citations
[1]Igawa H, et al., Discovery of a Novel Mutant-Selective Epidermal Growth Factor Receptor Inhibitor Using an In Silico Enabled Drug Discovery Platform. J Med Chem. 2024 Dec 26;67 (24) :21811-21840.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
