HDAC6 degrader-5

HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-α, IL-1β and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP (HY-66005) -induced liver injury models[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; HDAC; Interleukin Related

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Concentration

10mM

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCC1=CC(C(NC2=CC=CC=C2)=O)=NN1CC3=CC=C(C=C3)C(NO)=O

Molecular Formula

C21H22N4O3

Molecular Weight

378.42

References & Citations

[1]Cui H, et al., Discovery of N-Phenyl-5-propyl-1H-pyrazole-3-carboxamide, with Selective Inhibition and Degradation of HDAC6 for the Treatment of Acute Liver Injury. J Med Chem. 2025 Jan 9;68 (1) :531-554.