HDAC6 degrader-5
HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-α, IL-1β and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP (HY-66005) -induced liver injury models[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HDAC; Interleukin Related
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCC1=CC(C(NC2=CC=CC=C2)=O)=NN1CC3=CC=C(C=C3)C(NO)=O
Molecular Formula
C21H22N4O3
Molecular Weight
378.42
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6
Available Sizes
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