SEH inhibitor-19
SEH inhibitor-19 (Compound (R) -14i) is an orally active inhibitor for soluble epoxide hydrolase (sEH) with an IC50 of 1.2 nM. sEH inhibitor-19 inhibits the expression of TNF-α and IL-6, exhibits anti-inflammatory activity in mouse acute pancreatitis or Carrageenan -induced edema models[1].
Product Specifications
UNSPSC
12352005
Target
Epoxide Hydrolase; Interleukin Related; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(NCC1=CC=C(OC(F)(F)F)C=C1)NC2=CC(C3)=C(C=C2)C[C@@]4([H])N3CCC5=C4C=C(OC)C(OC)=C5
Molecular Formula
C28H28F3N3O4
Molecular Weight
527.53
References & Citations
[1]Liu XZ, et al., Redesigning Berberines and Sanguinarines to Target Soluble Epoxide Hydrolase for Enhanced Anti-Inflammatory Efficacy. J Med Chem. 2024 Dec 26;67 (24) :22168-22190.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![IRF3 Recombinant Rabbit monoclonal Antibody [SD2062]](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea822e6/imageurl/et1612-14-50ul.webp)
ET1612-14-50UL 50 µL
IRF3 Recombinant Rabbit monoclonal Antibody [SD2062]
Sign In for Pricing
View Details 
HA725133H 100 µL
Mouse Angiotensinogen Recombinant Rabbit monoclonal Antibody
Sign In for Pricing
View Details 