GSK-3β inhibitor 23
GSK-3β inhibitor 23 (Compound 11726169) is the inhibitor for glycogen synthase kinase-3, that inhibits GSK-3β and GSK-3α with IC50 of 12.1 nM and 18.8 nM. GSK-3β inhibitor 23 exhibits antiviral activity against HIV 1. GSK-3β inhibitor 23 exhibits good metabolic stablility in mouse/human liver microsomes and plasma, but poor Caco-2 permeability (which predicts low oral bioavailability) [1].
Product Specifications
UNSPSC
12352005
Target
GSK-3
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Infection; Neurological Disease
Smiles
ClC1=CC(Cl)=CC(NC2=NN(S(C3=CC=C(C=CC=C4)C4=C3)(=O)=O)C(N)=N2)=C1
Molecular Formula
C18H13Cl2N5O2S
Molecular Weight
434.30
References & Citations
[1]Jones T, et al., Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents. ACS Chem Neurosci. 2025 Jan 1;16 (1) :77-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β
Curated Selection
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