TTQ-SA

TTQ-SA is a near-infrared (NIR) spiro-AIEgen (aggregation-induced emission luminogen), that converts near-infrared light (NIR) into thermal energy, causing thermal damage and death of tumor cells. TTQ-SA exhibits cellular uptake and targeting ability in cancer cell MF-7. TTQ-SA silences the expression of survivin gene with combination of DNAzyme, enhances the sensitivity of tumor cells to photothermal therapy[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Photosensitizer

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

CC1(C)C2=C(C=CC=C2)N(C3=C4C=CC=C31)C5=C(C=CC=C5)C64C7=C(C=CC=C7)C(C(C8=C6C=CC=C8)=N9)=NC(C9=C(C%10=CC=C(N(C%11=CC=CC=C%11)C%12=CC=CC=C%12)C=C%10)C%13=NSN=C%13%14)=C%14C(C=C%15)=CC=C%15N(C%16=CC=CC=C%16)C%17=CC=CC=C%17

Molecular Formula

C78H53N7S

Molecular Weight

1120.37

References & Citations

[1]Chen Y, et al., Engineering a Near-Infrared Spiro-Based Aggregation-Induced Emission Luminogen for DNAzyme-Sensitized Photothermal Therapy with High Efficiency and Accuracy. J Am Chem Soc. 2024 Dec 25;146 (51) :35462-35477.