MLK3-IN-1
MLK3-IN-1 (Compound 37) is a selective inhibitor for mixed-lineage protein kinase 3 (MLK3) with an IC50 FAK with an IC50 of 15.5 μM. MLK3-IN-1 exhibits good metabolic stability in mouse and human liver microsomes[1].
Product Specifications
UNSPSC
12352005
Target
FAK; Mixed Lineage Kinase
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
FC(C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=CC=CC(S(=O)(C)=O)=C3)=N2)C=C1)(F)F
Molecular Formula
C20H16F6N4O2S
Molecular Weight
490.42
References & Citations
[1]Sander P, et al., Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example. J Med Chem. 2025 Jan 9;68 (1) :674-694.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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