Thrombin inhibitor 13
Thrombin inhibitor 13 (Compound 13a) is a covalent and reversible inhibitor for thrombin (FIIa) with an IC50 of 0.7 nM. Thrombin inhibitor 13 prolongs the activated partial thromboplastin time (aPTT) and prothrombin time (PT), exhibits antithrombotic and anticoagulant activities[1].
Product Specifications
UNSPSC
12352005
Target
Thrombin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
CC(C)(C)C(N1N=C(C2=NC=CN=C2)N=C1NCC3=CC=C(Cl)S3)=O
Molecular Formula
C16H17ClN6OS
Molecular Weight
376.86
References & Citations
[1]Imberg L, et al., Pyrazinyl-Substituted Aminoazoles as Covalent Inhibitors of Thrombin: Synthesis, Structure, and Anticoagulant Properties. ACS Pharmacol Transl Sci. 2024 Dec 11;8 (1) :146-172.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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