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Thrombin inhibitor 13

Thrombin inhibitor 13 (Compound 13a) is a covalent and reversible inhibitor for thrombin (FIIa) with an IC50 of 0.7 nM. Thrombin inhibitor 13 prolongs the activated partial thromboplastin time (aPTT) and prothrombin time (PT), exhibits antithrombotic and anticoagulant activities[1].

Product Specifications

UNSPSC

12352005

Target

Thrombin

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

CC(C)(C)C(N1N=C(C2=NC=CN=C2)N=C1NCC3=CC=C(Cl)S3)=O

Molecular Formula

C16H17ClN6OS

Molecular Weight

376.86

References & Citations

[1]Imberg L, et al., Pyrazinyl-Substituted Aminoazoles as Covalent Inhibitors of Thrombin: Synthesis, Structure, and Anticoagulant Properties. ACS Pharmacol Transl Sci. 2024 Dec 11;8 (1) :146-172.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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