KAI-11101
KAI-11101 is the inhibitor for dual leucine zipper kinase (DLK, MAP3K12) with a Ki of 0.7 nM. KAI-11101 inhibits Paclitaxel (HY-B0015) -induced cJun phosphorylation (IC50=95 nM) and thus inhibits the activation of MAPK pathway. KAI-11101 is blood brain barrier penetrable and can be further investigated for its neuroprotective property[1].
Product Specifications
UNSPSC
12352005
Target
MAP3K; p38 MAPK
Related Pathways
MAPK/ERK Pathway
Field of Research
Neurological Disease
Smiles
O=C1C(N(CC)N=C2C3=CC(OC(F)F)=C(N)N=C3)=C2C=CN1[C@H]4[C@@H](OC)CC(F)(F)CC4
Molecular Formula
C21H23F4N5O3
Molecular Weight
469.43
References & Citations
[1]Lagiakos HR, et al., In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury. J Med Chem. 2024 Dec 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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