Seldegamadlin

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[1]Yogesh Chutake, KT-253, a highly potent and selective heterobifunctional MDM2 degrader for the treatment of wildtype p53 tumors with superior potency and differentiated biological activity compared to small molecule inhibitors (SMI) . |[2]Min Lu, et al. KT-253, a Highly Potent and Selective MDM2 Protein Degrader, Eliminates Malignant Myelofibrosis Stem/Progenitor Cells. Blood. Volume 144, Supplement 1, 5 November 2024, Page 3588.|[3]Chutake YK, et al. KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule Inhibitors. Mol Cancer Ther. 2025;24 (4) :497-510.|[4]Nancy Dumont, et al. Predictive Markers of Response to the MDM2 Degrader KT-253.