Duvelisib (Standard)
Duvelisib (Standard) is the analytical standard of Duvelisib. This product is intended for research and analytical applications. Duvelisib (IPI-145) is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively[1][2].
Product Specifications
CAS Number
[1201438-56-3]
UNSPSC
12352100
Target
PI3K; Reference Standards
Related Pathways
Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=CC5=C1C(Cl)=CC=C5
Molecular Formula
C22H17ClN6O
Molecular Weight
416.86
References & Citations
[1]Pillinger G, et al. Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection. Oncotarget. 2016 Jun 28;7 (26) :39784-39795.|[2]G?ckeritz E, et al. Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells. Int J Cancer. 2015 Nov 1;137 (9) :2234-42.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17044R/
Scientific Category
Reference Standards
Available Sizes
Curated Selection
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