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E3 ligase Ligand 48

E3 ligase Ligand 48 is a CRBN ligand for PROTAC AR Degrader-9. PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC50 of 262.38 nM[1].

Product Specifications

UNSPSC

12352005

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Field of Research

Others

Smiles

O=C(C(CC1)NC(C(C=C2)=CC=C2N3CCCC(C=O)C3)=O)NC1=O

Molecular Formula

C18H21N3O4

Molecular Weight

343.38

References & Citations

[1]Xinfei Mao, et al. Discovery of a Novel Non-invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia. J Med Chem. 2024 Dec 26;67 (24) :22218-22244.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Frequently Asked Questions

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