E3 ligase Ligand 48
E3 ligase Ligand 48 is a CRBN ligand for PROTAC AR Degrader-9 (HY-170448) . PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC50 of 262.38 nM[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Others
Smiles
O=C(C(CC1)NC(C(C=C2)=CC=C2N3CCCC(C=O)C3)=O)NC1=O
Molecular Formula
C18H21N3O4
Molecular Weight
343.38
References & Citations
[1]Xinfei Mao, et al. Discovery of a Novel Non-invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia. J Med Chem. 2024 Dec 26;67 (24) :22218-22244.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Curated Selection
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