E3 ligase Ligand 48
E3 ligase Ligand 48 is a CRBN ligand for PROTAC AR Degrader-9. PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC50 of 262.38 nM[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Others
Smiles
O=C(C(CC1)NC(C(C=C2)=CC=C2N3CCCC(C=O)C3)=O)NC1=O
Molecular Formula
C18H21N3O4
Molecular Weight
343.38
References & Citations
[1]Xinfei Mao, et al. Discovery of a Novel Non-invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia. J Med Chem. 2024 Dec 26;67 (24) :22218-22244.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GP-3201-20 1 mL
Colloidal Gold Conjugated Cytisus sscoparius Lectin (Scotch broom) -CSA-, 20nm
Sign In for Pricing
View Details 
LY402011 100 µg
Fos B (FOSB) (NM_006732) Human Over-expression Lysate
Sign In for Pricing
View Details 