PROTAC AR Degrader-9

PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC50 of 262.38 nM. PROTAC AR Degrader-9 promotes the expressions of paracrine factors, such as TGF-β1 and β-catenin, exhibits hair regenerating efficacy in mouse models[1]. (Pink: ligand for target protein AR ligand-38 (HY-170450) ; Black: linker; Blue: ligand for E3 ligase Cereblon (HY-170449) )

Product Specifications

UNSPSC

12352005

Target

Androgen Receptor; PROTACs

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Smiles

O=C(N[C@H]1CC[C@H](OC2=CC(Cl)=C(C#N)C=C2)CC1)C3=CC=C(C4CCN(CC5CCCN(C5)C6=CC=C(C=C6)C(NC7CCC(NC7=O)=O)=O)CC4)C=C3

Molecular Formula

C43H49ClN6O5

Molecular Weight

765.34

References & Citations

[1]Mao X, et al., Discovery of a Novel Non-invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia. J Med Chem. 2024 Dec 26;67 (24) :22218-22244.