NOD1 antagonist-2
NOD1 antagonist-2 (compound 66) is an orally active selective antagonist of both human and mouse NOD1. NOD1 antagonist-2 (compound 66) antagonizes NOD1-induced NF-κB and MAPK pathways[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CS(C1=CC=C(N=C(Cl)N(C2=CC(NS(=O)(C3=C(F)C=CC=C3F)=O)=C(Cl)C=C2)C4=O)C4=C1)(=O)=O
Molecular Formula
C21H13Cl2F2N3O5S2
Molecular Weight
560.38
References & Citations
[1]Xinhua Liu, et al. Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection. J Med Chem. 2024 Dec 26;67 (24) :22145-22167.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOD1
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