NOD1 antagonist-2

NOD1 antagonist-2 (compound 66) is an orally active selective antagonist of both human and mouse NOD1. NOD1 antagonist-2 (compound 66) antagonizes NOD1-induced NF-κB and MAPK pathways[1].

Product Specifications

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

CS(C1=CC=C(N=C(Cl)N(C2=CC(NS(=O)(C3=C(F)C=CC=C3F)=O)=C(Cl)C=C2)C4=O)C4=C1)(=O)=O

Molecular Formula

C21H13Cl2F2N3O5S2

Molecular Weight

560.38

References & Citations

[1]Xinhua Liu, et al. Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection. J Med Chem. 2024 Dec 26;67 (24) :22145-22167.