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MyD88-IN-2

MyD88-IN-2 (compound A5S) is a Myeloid differentiation primary response 88 (MyD88) inhibitor with the Kd of 15 μM. MyD88-IN-2 shows protective effects on LPS -induced and sepsis-induced ALI mouse models[1].

Product Specifications

CAS Number

3067479-71-1

UNSPSC

12352005

Target

MyD88

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.400

Smiles

O[C@@H](CN1CCN(CC2=CC3=C(C=CC=C3)N2)CC1)COC4=CC=C(Br)C=C4

Molecular Formula

C22H26BrN3O2

Molecular Weight

444.36

References & Citations

[1]Chen P, et al. Discovery of Novel MyD88 Inhibitor A5S to Alleviate Acute Lung Injury with Favorable Drug-like Properties. J Med Chem. 2024;67 (24) :22263-22281.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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