MyD88-IN-2
MyD88-IN-2 (compound A5S) is a Myeloid differentiation primary response 88 (MyD88) inhibitor with the Kd of 15 μM. MyD88-IN-2 shows protective effects on LPS -induced and sepsis-induced ALI mouse models[1].
Product Specifications
CAS Number
3067479-71-1
UNSPSC
12352005
Target
MyD88
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.400
Smiles
O[C@@H](CN1CCN(CC2=CC3=C(C=CC=C3)N2)CC1)COC4=CC=C(Br)C=C4
Molecular Formula
C22H26BrN3O2
Molecular Weight
444.36
References & Citations
[1]Chen P, et al. Discovery of Novel MyD88 Inhibitor A5S to Alleviate Acute Lung Injury with Favorable Drug-like Properties. J Med Chem. 2024;67 (24) :22263-22281.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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