ADS1017
ADS1017 is the antagonist for histamine receptor and muscarinic receptor, that exhibits good affinities to hH3R, hH4R, hM2R and hM4R with pKi of 6.8, 5.5, 7.4 and 7.2. ADS1017 exhibits analgesic and anti-allodynic efficacy in mice Capsaicin (HY-10448) -or Oxaliplatin (HY-17371) -induced pain models[1].
Product Specifications
UNSPSC
12352005
Target
Histamine Receptor; mAChR
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
NC(N(CCCCN1CCN(CCCCCCCOC2=CC=CC=C2)CC1)CC3=CC=CC=C3)=N
Molecular Formula
C29H45N5O
Molecular Weight
479.70
References & Citations
[1]Karcz T, et al., Guanidine Derivative ADS1017, a Potent Histamine H3 Receptor Antagonist with Promising Analgesic Activity and Satisfactory Safety Profile. ACS Chem Neurosci. 2024 Dec 18;15 (24) :4441-4457.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
126428-ML550 100 µL
ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2, COFS2, EM9, MGC102762, MGC126218, MGC126219, TTD, XPD) (MaxLight 550)
Ask
View Details 
U2281-03-ML490 100 µL
Uridine Monophosphate Kinase 2, NT (Cytidine monophosphokinase 2, Testis-specific protein, UCK 2, UK, UMPK, Uridine-cytidine kinase 2, Uridine monophosphokinase 2) (MaxLight 490) discontinued
Ask
View Details bsm-52041R-BF488-01 20 µL
Collagen XVII Recombinant Antibody, AbBy Fluor™ 488 Conjugated
Ask
View Details 
bsm-52041R-BF488-02 100 µL
Collagen XVII Recombinant Antibody, AbBy Fluor™ 488 Conjugated
Ask
View Details H1827-56F-PE 100 µL
HDAC8 (Histone Deacetylase 8, HD 8, HD8, CDA07, Histone Deacetylase-like 1, HDACL1) (Azide Free) (PE)
Ask
View Details