ATV2301

ATV2301 is an orally active anti-influenza agent (EC50, H1N1 = 1.88 nM, H3N2 = 4.77 nM) . ATV2301’s anti-influenza activity is due to its effects on polymerase acid protein (PA), nuclear protein (NP), and RNA-dependent RNA polymerase (RdRp) [1].

Product Specifications

CAS Number

[3049172-60-0]

UNSPSC

12352005

Target

Influenza Virus

Related Pathways

Anti-infection

Field of Research

Infection; Inflammation/Immunology

Smiles

OC1=C(C(N2[C@@]3([H])COCC2)=O)N(C=CC1=O)N3[C@@H](C4=CC=C(F)C(F)=C4)C5=CC=CS5

Molecular Formula

C21H17F2N3O4S

Molecular Weight

445.44

References & Citations

[1]Yongzhi Chen, et al. Discovery of Novel Thiophene-Based Baloxavir Derivatives as Potent Cap-Dependent Endonuclease Inhibitors for Influenza Treatment. J Med Chem. 2024 Dec 26;67 (24) :22039-22054.