PARP1-IN-34

PARP1-IN-34 (compound 30) is a selective PARP1 inhibitor with an IC50 of 0.32 nM. PARP1-IN-34 is a subnanomolar PARP1 inhibitor with >1000-fold selectivity against PARP2 with an IC50 of 326 nM. PARP1-IN-34 shows antitumor efficacy[1].

Product Specifications

UNSPSC

12352005

Target

PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N1)[C@H](N2N=CC3=CC(CN4CCN(C(C=CC(C(NC)=O)=N5)=C5C)CC4)=CC1=C23)C

Molecular Formula

C23H27N7O2

Molecular Weight

433.51

References & Citations

[1]Gao S, Hou Y, et al. Discovery of Pyrazolo[1,5,4-de]quinoxalin-2 (3H) -one Derivatives as Highly Potent and Selective PARP1 Inhibitors. J Med Chem. 2024 Dec 12;67 (23) :21380-21399.