PARP1-IN-34
PARP1-IN-34 (compound 30) is a selective PARP1 inhibitor with an IC50 of 0.32 nM. PARP1-IN-34 is a subnanomolar PARP1 inhibitor with >1000-fold selectivity against PARP2 with an IC50 of 326 nM. PARP1-IN-34 shows antitumor efficacy[1].
Product Specifications
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N1)[C@H](N2N=CC3=CC(CN4CCN(C(C=CC(C(NC)=O)=N5)=C5C)CC4)=CC1=C23)C
Molecular Formula
C23H27N7O2
Molecular Weight
433.51
References & Citations
[1]Gao S, Hou Y, et al. Discovery of Pyrazolo[1,5,4-de]quinoxalin-2 (3H) -one Derivatives as Highly Potent and Selective PARP1 Inhibitors. J Med Chem. 2024 Dec 12;67 (23) :21380-21399.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PARP1; PARP2
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