SAL-0010042

SAL-0010042 is the inhibitor for Plasmodium phosphodiesterase β (PDEβ), that inhibits the hydrolysis of cAMP and cGMP (IC50=48.9 nM) in gametocytes, activates PKG, and inhibits the growth and development of Plasmodium (IC50 for 3D7 and Dd2 is 142 nM and 218 nM) . SAL-0010042 inhibits hPDE5 and hPDE6 with IC50 of 632 nM and 73 nM[1].

Product Specifications

CAS Number

[521298-46-4]

UNSPSC

12352005

Target

Parasite; Phosphodiesterase (PDE)

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C1N=C(CC2=C(F)C=CC=C2)NC3=C1NN=C3C(C)C

Molecular Formula

C15H15FN4O

Molecular Weight

286.30

References & Citations

[1]Gomez-Gonzalez PJ, et al., Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Sci Adv. 2024 Dec 6;10 (49) :eadq1383.