SAL-0010042
SAL-0010042 is the inhibitor for Plasmodium phosphodiesterase β (PDEβ), that inhibits the hydrolysis of cAMP and cGMP (IC50=48.9 nM) in gametocytes, activates PKG, and inhibits the growth and development of Plasmodium (IC50 for 3D7 and Dd2 is 142 nM and 218 nM) . SAL-0010042 inhibits hPDE5 and hPDE6 with IC50 of 632 nM and 73 nM[1].
Product Specifications
CAS Number
521298-46-4
UNSPSC
12352005
Target
Parasite; Phosphodiesterase (PDE)
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=C1N=C(CC2=C(F)C=CC=C2)NC3=C1NN=C3C(C)C
Molecular Formula
C15H15FN4O
Molecular Weight
286.30
References & Citations
[1]Gomez-Gonzalez PJ, et al., Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Sci Adv. 2024 Dec 6;10 (49) :eadq1383.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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