HGC652
HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21[1].
Product Specifications
CAS Number
3055558-98-7
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Molecular Glues
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.86
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CN(C(C1=CC=C(C2=C(SC)C=C(F)C=C2)C=C1S(=O)(C)=O)=O)CC3CCCCC3
Molecular Formula
C23H28FNO3S2
Molecular Weight
449.60
References & Citations
[1]Li X, et al. Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21[J]. bioRxiv, 2024: 2024.12. 03.626577.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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