HGC652

HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21[1].

Product Specifications

CAS Number

[3055558-98-7]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; Molecular Glues

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.86

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CN(C(C1=CC=C(C2=C(SC)C=C(F)C=C2)C=C1S(=O)(C)=O)=O)CC3CCCCC3

Molecular Formula

C23H28FNO3S2

Molecular Weight

449.60

References & Citations

[1]Li X, et al. Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21[J]. bioRxiv, 2024: 2024.12. 03.626577.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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