(S) -Cetirizine (dihydrochloride)
(S) -Cetirizine dihydrochloride ((S) -P071) is an orally active antagonist of the histamine H1 receptor with a Ki value of 39.1 nM. (S) -Cetirizine dihydrochloride exerts anti-allergic activity by binding to the histamine H1 receptor and blocking the action of histamine. (S) -Cetirizine dihydrochloride is promising for research of allergic diseases such as allergic rhinitis[1].
Product Specifications
CAS Number
[163837-48-7]
Product Name Alternative
(S) -P071
UNSPSC
12352005
Hazard Statement
H302
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC(COCCN(CC1)CCN1[C@@H](C2=CC=CC=C2)C3=CC=C(C=C3)Cl)=O.Cl.Cl
Molecular Formula
C21H27Cl3N2O3
Molecular Weight
461.81
Precautions
P264-P270-P330-P501
References & Citations
[1]Hishinuma S, et al. Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S) -Cetirizine by Lys191 in Human Histamine H₁ Receptors. Int J Mol Sci. 2018 Dec 15;19 (12) :4067.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor
Available Sizes
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