(S) -Cetirizine (dihydrochloride)

(S) -Cetirizine dihydrochloride ((S) -P071) is an orally active antagonist of the histamine H1 receptor with a Ki value of 39.1 nM. (S) -Cetirizine dihydrochloride exerts anti-allergic activity by binding to the histamine H1 receptor and blocking the action of histamine. (S) -Cetirizine dihydrochloride is promising for research of allergic diseases such as allergic rhinitis[1].

Product Specifications

CAS Number

[163837-48-7]

Product Name Alternative

(S) -P071

UNSPSC

12352005

Hazard Statement

H302

Target

Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

OC(COCCN(CC1)CCN1[C@@H](C2=CC=CC=C2)C3=CC=C(C=C3)Cl)=O.Cl.Cl

Molecular Formula

C21H27Cl3N2O3

Molecular Weight

461.81

Precautions

P264-P270-P330-P501

References & Citations

[1]Hishinuma S, et al. Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S) -Cetirizine by Lys191 in Human Histamine H₁ Receptors. Int J Mol Sci. 2018 Dec 15;19 (12) :4067.