BJP-07-017-3
BJP-07-017-3 is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 9 nM. BJP-07-017-3 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation[1].
Product Specifications
CAS Number
2468783-22-2
UNSPSC
12352005
Target
PIN1
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CN(C(CCl)=O)[C@H](C(N1CCCC[C@H]1C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(N)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC4=CC=CC=C4
Molecular Formula
C35H45ClN8O6
Molecular Weight
709.23
References & Citations
[1]Alboreggia G, et al., Targeted degradation of Pin1 by protein-destabilizing compounds. Proc Natl Acad Sci U S A. 2024 Nov 19;121 (47) :e2403330121.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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