BJP-07-017-3

BJP-07-017-3 is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 9 nM. BJP-07-017-3 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation[1].

Product Specifications

CAS Number

[2468783-22-2]

UNSPSC

12352005

Target

PIN1

Related Pathways

PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

CN(C(CCl)=O)[C@H](C(N1CCCC[C@H]1C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(N)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC4=CC=CC=C4

Molecular Formula

C35H45ClN8O6

Molecular Weight

709.23

References & Citations

[1]Alboreggia G, et al., Targeted degradation of Pin1 by protein-destabilizing compounds. Proc Natl Acad Sci U S A. 2024 Nov 19;121 (47) :e2403330121.