JNK-1-IN-5

JNK-1-IN-5 (Compound 14) is a potent JNK1 inhibitor with sub-nanomolar efficacy. JNK-1-IN-5 suppresses TGF-β-induced epithelial-mesenchymal transition. JNK-1-IN-5 is promising for research of anti-pulmonary fibrosis agent targeting JNK1[1].

Product Specifications

CAS Number

[3047794-08-8]

UNSPSC

12352005

Target

JNK

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Others

Smiles

O=C(C1=C(NC2=NC(NC3=CC=C(C(N4CC5OCC4C5)=O)C=C3)=NC=C2Br)C=CC=C1)N

Molecular Formula

C23H21BrN6O3

Molecular Weight

509.36

References & Citations

[1]Ren S, et al. Discovery of a selective and potent inhibitor of c-Jun N-terminal kinase 1 with anti-pulmonary fibrosis effect. Bioorg Med Chem Lett. 2025 Feb 1;116:130044.