ALK/ROS1-IN-5

ALK/ROS1-IN-5 (compound X4) is a selective ALK and ROS1 kinases inhibitor with IC50s of 0.512 μM (ALK), 0.766 μM (ROS1), respectively. ALK/ROS1-IN-5 inhibits H2228 cells with an IC50 of 0.034 μM. ALK/ROS1-IN-5 induces cancer cells apoptosis in dose-dependent manner. ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells[1].

Product Specifications

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; Apoptosis; ROS Kinase

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

FC1=CC(F)=CC(CC2=CC=C(NN=C3NC(C4=CC=C(C5=CC=C(OC)C=C5)C=C4N6CCOCC6)=O)C3=C2)=C1

Molecular Formula

C32H28F2N4O3

Molecular Weight

554.59

References & Citations

[1]Huang X, et al. Revealing 5- (3,5-difluorobenzyl) -1H-indazole as the active pharmacophore of ALK/ROS1 dual inhibitors through theoretical calculations and biological activity evaluations. Bioorg Chem. 2025 Jan;154:108014.