HAChE/hBuChE/GSK-3β-IN-1
HAChE/hBuChE/GSK-3β-IN-1 (Compound 6c) is a BBB-penetrable and multi-target anti-Alzheimer's disease compound. hAChE/hBuChE/GSK-3β-IN-1 is the inhibitors of hAChE (IC50: 28.88 nM), hBuChE (IC50: 131.90 nM) and GSK-3β (IC50: 51.42 nM) . hAChE/hBuChE/GSK-3β-IN-1 is the tau and Aβ protein aggregation inhibitors[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE) ; GSK-3
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(/C=C/NC1=CC=C(OC(C=C2)=O)C2=C1)C3=CC=C(OC)C=C3
Molecular Formula
C19H15NO4
Molecular Weight
321.33
References & Citations
[1]Abd El-Mageed MMA, et al. Rational design, synthesis and computational studies of multi-targeted anti-Alzheimer's agents integrating coumarin scaffold. Bioorg Chem. 2025 Jan;154:108024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; GSK-3β
Curated Selection
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