PROTAC BTK Degrader-12

PROTAC BTK Degrader-12 (EXAMPLE 19) is a PROTAC-based BTK degrader (Pink & black: BTK ligand & linker (HY-170414) ; Black: linker (HY-30105) ; Blue: CRBN ligand (HY-W245311) ) [1].

Product Specifications

CAS Number

[2736508-65-7]

UNSPSC

12352005

Target

Btk; PROTACs

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC(C)(C)C1=NOC(C(N[C@@H](C2=CC=C(C3=C4C(NC(C5=NC=C(N6CCN(CC7CCN(C8=CC=C(N9C(NC(CC9)=O)=O)C=C8)CC7)CC6)C=C5)=C4)=NC=N3)C=C2C)C)=O)=N1

Molecular Formula

C47H54N12O4

Molecular Weight

851.01

References & Citations

[1]Hexiang Wang, et al. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use. Patent WO2021219070A1.