PROTAC BTK Degrader-12
PROTAC BTK Degrader-12 (EXAMPLE 19) is a PROTAC-based BTK degrader (Pink & black: BTK ligand & linker ; Black: linker (HY-30105) ; Blue: CRBN ligand (HY-W245311) ).
Product Specifications
CAS Number
2736508-65-7
UNSPSC
12352005
Target
Btk; PROTACs
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(C)(C)C1=NOC(C(N[C@@H](C2=CC=C(C3=C4C(NC(C5=NC=C(N6CCN(CC7CCN(C8=CC=C(N9C(NC(CC9)=O)=O)C=C8)CC7)CC6)C=C5)=C4)=NC=N3)C=C2C)C)=O)=N1
Molecular Formula
C47H54N12O4
Molecular Weight
851.01
References & Citations
[1]Hexiang Wang, et al. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use. Patent WO2021219070A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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