WNT7A-IN-1
WNT7A-IN-1 (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 significantly increases the expression of MHC-I and p-p65, while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 (compound F) is also a photographic sensitizer in the green spectral region[1][2].
Product Specifications
CAS Number
29133-39-9
UNSPSC
12352005
Target
Wnt
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.66
Smiles
O=S([O-])(CCC[N+]1=C(/C=C(CC)/C=C2OC3=C(N\2CCCS(=O)(O)=O)C=C(C4=CC=CC=C4)C=C3)OC5=CC=C(C6=CC=CC=C6)C=C51)=O
Molecular Formula
C37H36N2O8S2
Molecular Weight
700.82
References & Citations
[1]Jiazheng Sun, et al. Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy. Cancer Immunol Res. 2024 Nov 27.|[2]I.Baraldi, et al. Dimerization of green sensitizing cyanines in solution. A spectroscopic and theoretical study of the bonding nature. Chemical Physics. Volume 275, Issues 1-3, 1 January 2002, Pages 149-165.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Wnt7
Available Sizes
Frequently Asked Questions
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