WNT7A-IN-1
WNT7A-IN-1 (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 significantly increases the expression of MHC-I and p-p65, while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 (compound F) is also a photographic sensitizer in the green spectral region[1][2].
Product Specifications
CAS Number
29133-39-9
UNSPSC
12352005
Target
Wnt
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.66
Smiles
O=S([O-])(CCC[N+]1=C(/C=C(CC)/C=C2OC3=C(N\2CCCS(=O)(O)=O)C=C(C4=CC=CC=C4)C=C3)OC5=CC=C(C6=CC=CC=C6)C=C51)=O
Molecular Formula
C37H36N2O8S2
Molecular Weight
700.82
References & Citations
[1]Jiazheng Sun, et al. Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy. Cancer Immunol Res. 2024 Nov 27.|[2]I.Baraldi, et al. Dimerization of green sensitizing cyanines in solution. A spectroscopic and theoretical study of the bonding nature. Chemical Physics. Volume 275, Issues 1-3, 1 January 2002, Pages 149-165.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Wnt7
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RPU55949-01 50 µg
Recombinant Mouse Purinergic Receptor P2X, Ligand Gated Ion Channel 4 (P2RX4)
Sign In for Pricing
View Details RPU55949-02 100 µg
Recombinant Mouse Purinergic Receptor P2X, Ligand Gated Ion Channel 4 (P2RX4)
Sign In for Pricing
View Details RPU55949-03 1 mg
Recombinant Mouse Purinergic Receptor P2X, Ligand Gated Ion Channel 4 (P2RX4)
Sign In for Pricing
View Details 
AK474118 96 Tests
Anti-SARS-CoV-2 Spike Protein (Trimer) Human IgM ELISA Kit
Sign In for Pricing
View Details 