BNN27
BNN27 is the agonist for TrkA receptor and p75NTR receptor, that exhibits neurotrophic and anti-apoptotic effects. BNN27 increases the levels of glutamate, GABA, and glutamine in the rat hippocampus and prefrontal cortex, improves glutamate turnover. BNN27 exhibits neuroprotective efficacy in mouse amyotrophic lateral sclerosis (ALS) model, exhibits anti-inflammatory efficacy in experimental autoimmune encephalomyelitis (EAE) model, exhibits retinal protective efficacy in rat diabete models. BNN27 is blood-brain barrier penetrable[1].
Product Specifications
CAS Number
[1195795-81-3]
UNSPSC
12352005
Target
Apoptosis; Trk Receptor
Related Pathways
Apoptosis; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
C[C@@]12[C@]3(CC[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)O)=CC4)C)([H])CC2)[C@H](O3)CO
Molecular Formula
C21H32O3
Molecular Weight
332.48
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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