YB-3–17
YB-3-17 is a bifunctional molecule, that inhibits mTOR (IC50=0.22 nM) or degrades G1 to S phase transition 1 gene (GSPT1, DC50=5 nM) in a PROTAC mechanism. YB-3-17 exhibits antiproliferative activity in multi glioblastoma cell lines with IC50 of nanomolare levels. YB-3-17 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein ; Black: linker (HY-A0102) ; Blue: ligand for E3 ligase Cereblon (HY-14658) )
Product Specifications
CAS Number
2940242-88-4
UNSPSC
12352005
Target
MTOR; PROTACs
Related Pathways
PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
NC(O1)=NC2=C1C=CC(C3=NN(C4CCN(C(C5CCC(CNC6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)=O)CC4)C9=NC=NC(N)=C93)=C2
Molecular Formula
C38H39N11O6
Molecular Weight
745.79
References & Citations
[1]Liu Y, et al., A Dual-Target and Dual-Mechanism Design Strategy by Combining Inhibition and Degradation Together. J Am Chem Soc. 2024 Dec 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD45RO (UCHL-1), CF488A conjugate, 0.1mg/mL
