YB-3–17
YB-3-17 is a bifunctional molecule, that inhibits mTOR (IC50=0.22 nM) or degrades G1 to S phase transition 1 gene (GSPT1, DC50=5 nM) in a PROTAC mechanism. YB-3-17 exhibits antiproliferative activity in multi glioblastoma cell lines with IC50 of nanomolare levels. YB-3-17 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-170407) ; Black: linker (HY-A0102) ; Blue: ligand for E3 ligase Cereblon (HY-14658) )
Product Specifications
CAS Number
[2940242-88-4]
UNSPSC
12352005
Target
MTOR; PROTACs
Related Pathways
PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
NC(O1)=NC2=C1C=CC(C3=NN(C4CCN(C(C5CCC(CNC6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)=O)CC4)C9=NC=NC(N)=C93)=C2
Molecular Formula
C38H39N11O6
Molecular Weight
745.79
References & Citations
[1]Liu Y, et al., A Dual-Target and Dual-Mechanism Design Strategy by Combining Inhibition and Degradation Together. J Am Chem Soc. 2024 Dec 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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