KF-52

KF-52 is a phosphofructokinase-1 (PFK1) inhibitor, with an IC50 of 2.1 μM. KF-52 significantly increases the OCR/ECAR (OCR: oxygen consumption rate; ECAR: extracellular acidification rate) ratio[1].

Product Specifications

CAS Number

[3104612-74-7]

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Purity

98.94

Smiles

[H][C@]1([C@H]([C@H]2C(O)=O)C(N(CCC3=C4NC5=C3C=CC=C5)[C@@H]4C(F)(F)F)=O)C[C@@]2(C=C1)[H]

Molecular Formula

C21H19F3N2O3

Molecular Weight

404.38

References & Citations

[1]Ryo Kakehi, et al. Asymmetric Synthesis, Structure Determination, and Biologic Evaluation of Isomers of TLAM as PFK1 Inhibitors. ACS Med Chem Lett. 2024 Dec 4;16 (1) :59-63.