LSD1-IN-38

LSD1-IN-38 (Compound 23e) is a reversible, orally active inhibitor for lysine specific demethylase 1 (LSD1) with an IC50 of 1.2 nM. LSD1-IN-38 inhibits the proliferation of cancer cells MV4-11, Kasumi-1 and NCI-H526, with IC50 of 5, 4 and 11 nM, respectively. LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 μM, and induces differentiation in MV4 11 cell. LSD1-IN-38 exhibits antitumor efficacy in mouse models[1].

Product Specifications

UNSPSC

12352005

Target

Histone Demethylase

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

FC1=C(C#N)C=CC(C2=C(N=CC3=C2C=C(CN4C[C@@H](N)CC4)N3CC(F)(F)F)C5=CC(C)=C(C)C=C5C)=C1

Molecular Formula

C30H29F4N5

Molecular Weight

535.58

References & Citations

[1]Jiang H, et al., Optimization and Biological Evaluation of Novel 1H-Pyrrolo[2,3-c]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia. J Med Chem. 2024 Dec 26;67 (24) :22080-22103.