SIRT6-IN-4

SIRT6-IN-4 (Compound 10d) is a selective inhibitor for SIRT6 with an IC50 of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC50 of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis. SIRT6-IN-4 exhibits antitumor efficacy in mouse models[1].

Product Specifications

CAS Number

[3075160-74-3]

UNSPSC

12352005

Target

Apoptosis; Sirtuin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C1=CC2=C(N(C3=C2C=C(C=C3)Cl)CC4=CC=C(C=C4)C#N)C=N1)NCC5=CC=CC=N5

Molecular Formula

C26H18ClN5O

Molecular Weight

451.91

References & Citations

[1]Liang C, et al., Structure-Guided Discovery of Subtype Selective SIRT6 Inhibitors with a β-Carboline Skeleton for the Treatment of Breast Cancer. J Med Chem. 2024 Dec 26;67 (24) :21975-22001.