SARS-CoV-2 PLpro-IN-1
SARS-CoV-2 PLpro-IN-1 (Compound 85) is a non-covalent and competitive inhibitor of SARS-CoV-2 PLpro with an IC50 of 15.06 μM and a Ki of 22.93 μM. SARS-CoV-2 PLpro-IN-1 inhibits the proliferation of Vero cell with an IC50 of 7.47 μM[1].
Product Specifications
CAS Number
[3053753-61-7]
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Related Pathways
Anti-infection
Field of Research
Cancer; Infection
Smiles
COC1=NC=C(C=C1)C2=NC3=C(C=C2)N=CC=C3N[C@@H]4CCNC4
Molecular Formula
C18H19N5O
Molecular Weight
321.38
References & Citations
[1]Sousa BKP, et al., Discovery of Non-Covalent Inhibitors for SARS-CoV-2 PLpro: Integrating Virtual Screening, Synthesis, and Experimental Validation. ACS Med Chem Lett. 2024 Dec 2;15 (12) :2140-2149.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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