ZG297
ZG297 is an agonist for Staphylococcus aureus ClpP (SaClpP) with an EC50 of 0.26 μM. ZG297 degrades SaFtsZ, inhibits the bacterial cell division, thereby exhibiting antistaphylococcal activity, that inhibits S. aureus 8325-4 strains and MRSA strains with MIC of 0.063-256 μg/mL. ZG297 exhibits anti-infectious efficacy in mouse models[1].
Product Specifications
CAS Number
2999673-52-6
UNSPSC
12352005
Target
Antibiotic; Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
FC(F)(F)CCCNC(N1[C@](CN(CC2=CC(C=CC=C3)=C3C4=C2C=CC=C4)C([C@@H]5[C@H](CC)C)=O)([H])N5C(CC1)=O)=O
Molecular Formula
C31H35F3N4O3
Molecular Weight
568.63
References & Citations
[1]Zhang T, et al., Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents. Cell Rep Med. 2024 Dec 17;5 (12) :101837.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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