ZG297

ZG297 is an agonist for Staphylococcus aureus ClpP (SaClpP) with an EC50 of 0.26 μM. ZG297 degrades SaFtsZ, inhibits the bacterial cell division, thereby exhibiting antistaphylococcal activity, that inhibits S. aureus 8325-4 strains and MRSA strains with MIC of 0.063-256 μg/mL. ZG297 exhibits anti-infectious efficacy in mouse models[1].

Product Specifications

CAS Number

[2999673-52-6]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

FC(F)(F)CCCNC(N1[C@](CN(CC2=CC(C=CC=C3)=C3C4=C2C=CC=C4)C([C@@H]5[C@H](CC)C)=O)([H])N5C(CC1)=O)=O

Molecular Formula

C31H35F3N4O3

Molecular Weight

568.63

References & Citations

[1]Zhang T, et al., Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents. Cell Rep Med. 2024 Dec 17;5 (12) :101837.