ABCG2-IN-4
ABCG2-IN-4 (Compound K31) is an orally active inhibitor for ABCG2, which reduces the release of Protoporphyrin IX (PPIX) from erythrocytes into plasma, and prevents the reduces phototoxicity. ABCG2-IN-4 exhibits anti-inflammatory and antioxidant activity in mouse models[1].
Product Specifications
CAS Number
2559759-63-4
UNSPSC
12352005
Target
BCRP
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C([C@H](CC(NC(C)C)=O)NC1=O)N([C@H]1C2)[C@@H](CC(C)C)C3=C2C4=CC=C(OC)C=C4N3
Molecular Formula
C24H32N4O4
Molecular Weight
440.54
References & Citations
[1]Zhu J, et al., Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria. Nat Commun. 2024 Dec 4;15 (1) :10557.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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