Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Agomelatine (hydrochloride) (Standard)

Agomelatine (hydrochloride) (Standard) is the analytical standard of Agomelatine (hydrochloride) . This product is intended for research and analytical applications. Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

Product Specifications

CAS Number

1176316-99-6

UNSPSC

12352100

Target

5-HT Receptor; Endogenous Metabolite; Melatonin Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

CC(NCCC1=C2C=C(OC)C=CC2=CC=C1)=O.Cl

Molecular Formula

C15H18ClNO2

Molecular Weight

279.76

References & Citations

[1]Audinot V, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367 (6) :553-61.|[2]Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306 (3) :954-64.|[3]Aguiar CC, et al. Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. Cell Mol Neurobiol. 2013 Aug;33 (6) :825-35.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Frozen Tissue Sections, Skin
CS503192 5x 5 µm

Frozen Tissue Sections, Skin

Sign In for Pricing
View Details
Shank1 Mouse Gene Knockout Kit (CRISPR)
KN515733 1 Kit

Shank1 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
BAP1 (BRCA1 Associated Protein 1) (BAP1/2667), CF594 conjugate, 0.1mg/mL
BNC942667-100 1x 100 µL

BAP1 (BRCA1 Associated Protein 1) (BAP1/2667), CF594 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Hyoscine Hydrobromide Trihydrate
TRC-H674308-1G 1 g

Hyoscine Hydrobromide Trihydrate

Sign In for Pricing
View Details
SENP5 Antibody
8C0368-AAT 50 µg

SENP5 Antibody

Sign In for Pricing
View Details
Tcl1 (TCL1A) (NM_021966) Human Recombinant Protein
TP304243M 100 µg

Tcl1 (TCL1A) (NM_021966) Human Recombinant Protein

Sign In for Pricing
View Details